Protein Details: Aquaporin-8

Protein ID

ICDB_Pro_0015

Protein Name

Aquaporin-8

Gene Name

AQP8; BCIN_08g00120

Organism

Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea)

Length

325 amino acids

AlphaFoldDB

AF-A0A384JP03-F1-model_v4.pdb

Function

Plasma membrane water channel that regulates the reactive oxygen species (ROS)-signaling pathway through its capacity to act as a membrane channel for hydrogen peroxide uptake . Required for the formation of infection structures and infection; especially on host leaves where it is essential for the penetration into the host . Regulates the expression of proteins related to redox-regulation and intracellular signal transduction and plays a role in the distribution of mitochondria in the hyphae .

Sequence

MALRSPARDYLVSMIGELVGTFLFLFFAFAAAQTANQPNGTKPLTPNATDTSKLLYIALAFGASLAANVWVFFRVSGGQFNPAVTLALVLIRAVSPTKALILIPAQLVGGSLAAAAVKGIIPGDDILFAVSLGPGVANVQGLFIELLLTFMLVFTILMLVAEKTKSTFVAPIGIGFSLFIGHLVGIFWTGAGINPARAFSPALIQASFPSYHWIYWLGPALGSFLAAGLYLGLKEMKYELVGGDADKEKREEGLTVQQADLIIETLRGLPRAIQGSGALGQFEGTTEGHRSPVDLERGAEVRILEDDPHIRKSRYGSPDSTDLPT

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1371/journal.pgen.1002230; 10.1128/ec.00164-12; 10.1111/mpp.12384; 10.1111/nph.13721

RefSeq

XP_001547129.1